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SCR7 pyrazine

SIGMA/SML1546 - ≥98% (HPLC)

Synonym: 2,3-Dihydro-6,7-diphenyl-2-thioxo-4(1H)-pteridinone; 6,7-Diphenyl-2-thio-lumazine (8CI)

CAS Number: 14892-97-8
Empirical Formula (Hill Notation): C18H12N4OS
Molecular Weight: 332.38
MDL Number: MFCD02167478
Linear Formula: C18H12N4OS
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1546-5MG 5 mg
 $108.00
1/EA		 Add To Favorites
45-SML1546-25MG 25 mg
 $435.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color faintly yellow to dark yellow
form powder
InChI 1S/C18H12N4OS/c23-17-15-16(21-18(24)22-17)20-14(12-9-5-2-6-10-12)13(19-15)11-7-3-1-4-8-11/h1-10H,(H2,20,21,22,23,24)
InChI key GSRTWXVBHGOUBU-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C(C1=C(N2)N=C(C3=CC=CC=C3)C(C4=CC=CC=C4)=N1)NC2=S
solubility DMSO: 10 mg/mL, clear
storage temp. room temp
Application: SCR7 pyrazine has been shown to enhance CRISPR genome editing efficiency. To see other small molecule CRISPR enhancers, visit sigma.com/CRISPR-enhancers .
Application: SCR7 pyrazine has been used as a non-homologous end joining (NHEJ) modulator to study its effect on CRISPR/Cas9-mediated editing.
Biochem/physiol Actions: SCR7 pyrazine is reported to be an inhibitor of non-homologous end joining (NHEJ) and has been shown to enhance the efficiency of CRISPR-Cas9 genome editing. The effect of SCR7 pyrazine on the efficiency and targeting precision of CRISPR applications has been shown to be cell type specific and context dependent. SCR7 pyrazine is a product of spontaneous cyclization of SCR7, first reported by Srivastava, M., et al.
General description: SCR7 pyrazine is an inhibitor of DNA ligase IV.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P301 + P312 + P330
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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