RN-9893

SIGMA/SML1547 - ≥98% (HPLC)

Synonym: N-(4-(4-Isopropylpiperazin-1-ylsulfonyl)phenyl)-2-nitro-4-(trifluoromethyl)benzamide

CAS Number: 1803003-68-0
Empirical Formula (Hill Notation): C₂₁H₂₃F₃N₄O₅S
Molecular Weight: 500.49
Linear Formula: C₂₁H₂₃F₃N₄O₅S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1547-5MG	5 mg	$108.00 1/EA		Add To Favorites
45-SML1547-25MG	25 mg	$348.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
InChI key	KORKKQLDGMHNKO-UHFFFAOYSA-N
Quality Level	100
SMILES string	O=C(NC1=CC=C(S(=O)(N2CCN(C(C)C)CC2)=O)C=C1)C3=CC=C(C(F)(F)F)C=C3[N+]([O-])=O
solubility	DMSO: 25 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	RN-9893 is a potent and selective antagonist of the Transient Receptor Potential ion channel TRPV4. RN-9893 has IC₅₀ values of 420 nM, 660 nM, and 320 nM for human, rat and mouse TRPV4 receptors, respectively. RN-9893 shows excellent selectivity over related TRP receptors with no inhibition of TRPV1 at a concentration of 10 μM, an IC₅₀ >30 μM against TRPV3, an IC₅₀ of approximately 30 μM against TRPM8, and also good selectivity using 54 binding assays against common biological targets.
General description:	RN-9893 is a small, orally bioavailable antagonist of TRPV4 (transient receptor potential subfamily V4. It is a tri-substituted benzamide compound.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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