Zibotentan

SIGMA/SML1550 - ≥98% (HPLC)

Synonym: N-(3-methoxy-5-methylpyrazin-2-yl)-2-(4-[1,3,4-oxadiazol-2-yl]phenyl)pyridine-3-sulfonamide; ZD4054

CAS Number: 186497-07-4
Empirical Formula (Hill Notation): C₁₉H₁₆N₆O₄S
Molecular Weight: 424.43
MDL Number: MFCD09955343
Linear Formula: C₁₉H₁₆N₆O₄S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1550-5MG	5 mg	$101.00 1/EA	Add To Favorites
45-SML1550-25MG	25 mg	$408.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C19H16N6O4S/c1-12-10-21-17(19(23-12)28-2)25-30(26,27)15-4-3-9-20-16(15)13-5-7-14(8-6-13)18-24-22-11-29-18/h3-11H,1-2H3,(H,21,25)
InChI key	FJHHZXWJVIEFGJ-UHFFFAOYSA-N
Quality Level	100
SMILES string	O=S(C1=C(C2=CC=C(C3=NN=CO3)C=C2)N=CC=C1)(NC4=NC=C(C)N=C4OC)=O
solubility	DMSO: 5 mg/mL, clear (warmed)
storage temp.	−20°C

Biochem/physiol Actions:	Zibotentan has been found to inhibit cell proliferation, invasion and metastasis in cancer models. In clinical trials on patients with castration-resistant prostate cancer and bone metastasis, who were pain-free or had mild pain, zibotentan treatment resulted in better overall survival as compared to placebo.
Biochem/physiol Actions:	Zibotentan is a potent and selective endothelin ET(A) receptor antagonist with an IC₅₀ of 21 nM for the ETA receptor subtype and no binding observed even at 10,000 nM for ETB.
Biochem/physiol Actions:	Zibotentan is a potent and selective endothelin ET(A) receptor antagonist.
General description:	Zibotentan is an orally bioavailable, non-peptide ET_A (endothelin) receptor-specific antagonist, with no activity against ET_B receptor.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P301 + P312 + P330
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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