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Zibotentan

SIGMA/SML1550 - ≥98% (HPLC)

Synonym: N-(3-methoxy-5-methylpyrazin-2-yl)-2-(4-[1,3,4-oxadiazol-2-yl]phenyl)pyridine-3-sulfonamide; ZD4054

CAS Number: 186497-07-4
Empirical Formula (Hill Notation): C19H16N6O4S
Molecular Weight: 424.43
MDL Number: MFCD09955343
Linear Formula: C19H16N6O4S
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-SML1550-5MG 5 mg
$108.00
1/EA
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45-SML1550-25MG 25 mg
$435.00
1/EA
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C19H16N6O4S/c1-12-10-21-17(19(23-12)28-2)25-30(26,27)15-4-3-9-20-16(15)13-5-7-14(8-6-13)18-24-22-11-29-18/h3-11H,1-2H3,(H,21,25)
InChI key FJHHZXWJVIEFGJ-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=S(C1=C(C2=CC=C(C3=NN=CO3)C=C2)N=CC=C1)(NC4=NC=C(C)N=C4OC)=O
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. −20°C
Biochem/physiol Actions: Zibotentan has been found to inhibit cell proliferation, invasion and metastasis in cancer models. In clinical trials on patients with castration-resistant prostate cancer and bone metastasis, who were pain-free or had mild pain, zibotentan treatment resulted in better overall survival as compared to placebo.
Biochem/physiol Actions: Zibotentan is a potent and selective endothelin ET(A) receptor antagonist with an IC50 of 21 nM for the ETA receptor subtype and no binding observed even at 10,000 nM for ETB.
General description: Zibotentan is an orally bioavailable, non-peptide ETA (endothelin) receptor-specific antagonist, with no activity against ETB receptor.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P301 + P312 + P330
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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