GV-58
SIGMA/SML1551 - ≥97% (HPLC)
Synonym: (2R)
CAS Number: 1402821-41-3
Empirical Formula (Hill Notation): C18H26N6OS
Molecular Weight: 374.50
MDL Number: MFCD28385865
Linear Formula: C18H26N6OS
Product Type: Chemical
| assay | ≥97% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C18H26N6OS/c1-4-8-24-1 |
| InChI key | DPTXJOUVBMUSGY-CYBMUJFWSA |
| Quality Level | 100  |
| SMILES string | CCCN1C2=NC(N[C@H](CC)CO)= |
| solubility | DMSO: 20 mg/mL, clear |
| storage condition | desiccated |
| storage temp. | −20°C |
| Biochem/physiol Actions: | GV-58 is a roscovitine analog that retains the ability to prolong the open state of calcium channels, but unlike roscovitine, is inactive against Cdk activity. GV-58 is a selective agonist of N-type and P/Q type calcium channels, which are critical to the triggering of neurotransmitter release at the neuromuscular junction. GV-58 has been studied as a possible therapeutic agent in a mouse model of Lambert-Eaton myasthenic syndrome (LEMS). The EC50 values for activation of N-, P/Q- and L- type calcium channels are 6.8, 9.9 and >100 μM, respectively. |
| Biochem/physiol Actions: | GV-58 is a selective agonist of N-type and P/Q type calcium channels. |
| Packaging: | 1, 5 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 |
| Precautionary statements | P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |