S3QEL 2
SIGMA/SML1554
Synonym: 1-
CAS Number: 890888-12-7
Empirical Formula (Hill Notation): C19H25N5
Molecular Weight: 323.44
Linear Formula: C19H25N5
Product Type: Chemical
| color | white to beige |
| form | powder |
| Quality Level | 100  |
| solubility | DMSO: 5 mg/mL, clear |
| storage temp. | −20°C |
| Biochem/physiol Actions: | S3QEL 2 is a selective inhibitor of superoxide production from the outer Q-binding site of mitochondrial respiratory complex site III (IIIQo) without altering oxidative phosphorylation. Site IIIQo is the primary source of mitochondrial reactive oxygen species (ROS) and has been implicated in a broad range of ROS-mediated signaling and pathology. S3QEL 2 lowered HIF-1α induction, protected against ROS-induced, JNK-mediated cell stress in pancreatic beta-cells, and decreased the oxidative stress-induced apoptosis that limits the yield of functional β-cells from intact islets. |
| Biochem/physiol Actions: | S3QEL 2, a cell permeable substituted allopurinol, is also known as 1-(3,4-Dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine. |
| Packaging: | 10, 50 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |