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AEM1

SIGMA/SML1556 - ≥98% (HPLC)

Synonym: ARE expression modulator 1; N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-thieno[2,3-d]pyrimidin-4-amine

CAS Number: 1030123-90-0
Empirical Formula (Hill Notation): C20H14FN3O2S
Molecular Weight: 379.41
Linear Formula: C20H14FN3O2S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1556-5MG 5 mg
 $108.00
1/EA		 Add To Favorites
45-SML1556-25MG 25 mg
 $435.00
1/EA		 Add To Favorites
assay ≥98% (HPLC)
color white to light brown
form powder
Quality Level 100 
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: AEM1 (ARE expression modulator 1) is also a selective inhibitor of sirtuin 2, which is a protein deacetylase mediated by NAD+. Sirtuin 2 supports tumor cell proliferation, thus its inhibition stimulates cell death in tumors.
Biochem/physiol Actions: AEM1 is a potent inhibitor of deregulated Nrf2 transcriptional activity. AEM1 broadly decreases the expression of NRF2 controlled genes and sensitizes A549 cells to various chemotherapeutic agents.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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