AEM1

SIGMA/SML1556 - ≥98% (HPLC)

Synonym: ARE expression modulator 1; N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-thieno[2,3-d]pyrimidin-4-amine

CAS Number: 1030123-90-0
Empirical Formula (Hill Notation): C₂₀H₁₄FN₃O₂S
Molecular Weight: 379.41
Linear Formula: C₂₀H₁₄FN₃O₂S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1556-5MG	5 mg	$101.00 1/EA	Add To Favorites
45-SML1556-25MG	25 mg	$408.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to light brown
form	powder
InChI	1S/C20H14FN3O2S/c21-14-4-2-13(3-5-14)15-9-27-20-18(15)19(23-10-24-20)22-8-12-1-6-16-17(7-12)26-11-25-16/h1-7,9-10H,8,11H2,(H,22,23,24)
InChI key	QGYLTGSHWIGJJD-UHFFFAOYSA-N
Quality Level	100
SMILES string	Fc1ccc(cc1)c2c3c([s]c2)[nH]cn[c]3=NCc4cc5c(cc4)OCO5
solubility	DMSO: 20 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	AEM1 (ARE expression modulator 1) is also a selective inhibitor of sirtuin 2, which is a protein deacetylase mediated by NAD⁺. Sirtuin 2 supports tumor cell proliferation, thus its inhibition stimulates cell death in tumors.
Biochem/physiol Actions:	AEM1 is a potent inhibitor of deregulated Nrf2 transcriptional activity.
Biochem/physiol Actions:	AEM1 is a potent inhibitor of deregulated Nrf2 transcriptional activity. AEM1 broadly decreases the expression of NRF2 controlled genes and sensitizes A549 cells to various chemotherapeutic agents.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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