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Yoda1

SIGMA/SML1558 - ≥98% (HPLC)

Synonym: 2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-pyrazine

CAS Number: 448947-81-7
Empirical Formula (Hill Notation): C13H8Cl2N4S2
Molecular Weight: 355.27
Linear Formula: C13H8Cl2N4S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1558-5MG 5 mg
 $111.00
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45-SML1558-25MG 25 mg
 $447.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C13H8Cl2N4S2/c14-9-2-1-3-10(15)8(9)7-20-13-19-18-12(21-13)11-6-16-4-5-17-11/h1-6H,7H2
InChI key BQNXBSYSQXSXPT-UHFFFAOYSA-N
Quality Level 100 
SMILES string [s]1c(nnc1c3nccnc3)SCc2c(cccc2Cl)Cl
solubility DMSO: 15 mg/mL, clear
storage temp. 2-8°C
Application: Yoda1 has been used to investigate its effect on heterotrimeric Piezo1 channels.
Biochem/physiol Actions: Yoda1 is a specific activator of mouse and human cation channel Piezo1, a mechanosensitive channel that mediates Ca2+ influx on mechanical activation and has been linked to a role in blood vessel development. Yoda1 stabilizes the Piezo1 open channel. In red blood cells, this was followed by downstream activation of the KCa3.1 Gardos channel with resultant calcium influx and potassium and water efflux, causing shrinkage of the cells. Yoda1 is the first Piezo1 agonist, giving the first evidence of non-mechanical activation of a Piezo channel.
General description: Yoda1 is a novel synthetic small molecule developed to study the kinetics, regulation and function of the cation channel Piezo-type mechanosensitive ion channel component 1 (Piezo1).
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P301 + P312 + P330
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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