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Furamidine dihydrochloride

SIGMA/SML1559 - ≥98% (HPLC)

Synonym: 2,5-Bis(4-amidinophenyl)furan dihydrochloride; 4,4′-(2,5-Furandiyl)bis-benzenecarboximidamide dihydrochloride; DB 75; DB75; NSC 305831; WR199385

CAS Number: 55368-40-6
Empirical Formula (Hill Notation): C18H16N4O · 2HCl
Molecular Weight: 377.27
Linear Formula: C18H16N4O · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1559-5MG 5 mg
 $119.00
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45-SML1559-25MG 25 mg
 $480.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C18H16N4O.2ClH/c19-17(20)13-5-1-11(2-6-13)15-9-10-16(23-15)12-3-7-14(8-4-12)18(21)22;;/h1-10H,(H3,19,20)(H3,21,22);2*1H
InChI key VXNYQUQHOUERTR-UHFFFAOYSA-N
Quality Level 100 
SMILES string [Cl-].[Cl-].N[C+](N)c1ccc(cc1)c2[o]c(cc2)c3ccc(cc3)[C+](N)N
solubility H2O: 1 mg/mL, clear (warmed)
storage condition desiccated
storage temp. −20°C
Biochem/physiol Actions: Furamidine (DB75) binds to strings of AT base pair sequences in DNA′s minor groove. Furamidine was originally developed as an anti-parasitic compound for a variety of diseases including Chagas′ disease. Furamidine targets AT rich sequences in trypanosome kinetoplast minicircle DNA (kDNA), resulting in subsequent destruction of the kinetoplast and cell death. Furamidine has also been found to inihbit tyrosyl-DNA phosphodiesterase (Tdp1) and act as a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4μM.
General description: Furamidine dihydrochloride is an analog of the aromatic drug pentamidine and a substrate of the organic cation transporter 1 (OCT1). A number of prodrugs of furamidine dihydrochloride are being synthesised and are in clinical trial stages.
Packaging: 5 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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