LP-211
SIGMA/SML1561 - ≥98% (HPLC)
Synonym: 6-
CAS Number: 1052147-86-0
Empirical Formula (Hill Notation): C30H34N4O
Molecular Weight: 466.62
MDL Number: MFCD22690843
Linear Formula: C30H34N4O
Product Type: Chemical
assay | ≥98% (HPLC) |
color | colorless |
form | film |
InChI | 1S/C30H34N4O/c31-23-25-14 |
InChI key | BQEDZLDNNBDKDS-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | O=C(NCC1=CC=C(C#N)C=C1)CC |
solubility | DMSO: 5 mg/mL, clear (warmed) |
storage temp. | 2-8°C |
Biochem/physiol Actions: | LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor with a Ki value of 0.58 nM at rat cloned 5-HT7 receptors, and >300-fold selectivity over the 5-HT1A receptor. The 5-HT7 receptor is involved in a variety of central nervous system functions including circadian rhythm, sleep, thermoregulation, nociception, and memory, and appears to be involved in cognitive disorders, anxiety, and depression. LP-211 has been used as a selective 5-HT7 receptor agonist in multiple models including studies as a potential therapeutic agent in models of Rett syndrome and Fragile X Syndrome. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |