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LP-211

SIGMA/SML1561 - ≥98% (HPLC)

Synonym: 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid 4-cyano-benzylamide; N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide; N-[(4-Cyanophenyl)methyl]-4-[1,1′-biphenyl]-2-yl-1-piperazinehexanamide

CAS Number: 1052147-86-0
Empirical Formula (Hill Notation): C30H34N4O
Molecular Weight: 466.62
MDL Number: MFCD22690843
Linear Formula: C30H34N4O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1561-5MG 5 mg
 $134.00
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45-SML1561-25MG 25 mg
 $543.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color colorless
form film
InChI 1S/C30H34N4O/c31-23-25-14-16-26(17-15-25)24-32-30(35)13-5-2-8-18-33-19-21-34(22-20-33)29-12-7-6-11-28(29)27-9-3-1-4-10-27/h1,3-4,6-7,9-12,14-17H,2,5,8,13,18-22,24H2,(H,32,35)
InChI key BQEDZLDNNBDKDS-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C(NCC1=CC=C(C#N)C=C1)CCCCCN2CCN(C3=CC=CC=C3C4=CC=CC=C4)CC2
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor with a Ki value of 0.58 nM at rat cloned 5-HT7 receptors, and >300-fold selectivity over the 5-HT1A receptor. The 5-HT7 receptor is involved in a variety of central nervous system functions including circadian rhythm, sleep, thermoregulation, nociception, and memory, and appears to be involved in cognitive disorders, anxiety, and depression. LP-211 has been used as a selective 5-HT7 receptor agonist in multiple models including studies as a potential therapeutic agent in models of Rett syndrome and Fragile X Syndrome.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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