HIV inhibitor 18A
SIGMA/SML1562 - ≥98% (HPLC)
Synonym: 18A; N-
CAS Number: 331261-50-8
Empirical Formula (Hill Notation): C14H11N5O2S
Molecular Weight: 313.33
Linear Formula: C14H11N5O2S
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| Quality Level | 100  |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | HIV inhibitor 18A is a broad spectrum viral fusion and viral entry inhibitor. HIV entry requires several steps in sequence starting with HIV surface glycoprotein gp120 binding to the CD4 receptor followed by a conformational change in gp120, exposing a second recognition site that binds the co-receptor C-C chemokine receptor (CCR5) on the host cell, eventually resulting in the fusion of HIV and the T cell membranes, allowing entry of the viral core into the cell. HIV inhibitor 18A prevents the surface envelope glycoprotein from fusing with host cells by blocking envelope glycoprotein transitions critical for entry rather than interfering with CD4 or CCR5 binding. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |