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BAY-678

SIGMA/SML1563 - ≥98% (HPLC)

Synonym: 2-Pyridinecarbonitrile, 5-[(4R)-5-acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-; 5-{(4R)-5-Acetyl-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidin-4-yl}pyridine-2-carbonitrile

CAS Number: 675103-36-3
Empirical Formula (Hill Notation): C20H15F3N4O2
Molecular Weight: 400.35
MDL Number: MFCD29924806
Linear Formula: C20H15F3N4O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1563-5MG 5 mg
 $119.00
1/EA		 Add To Favorites
45-SML1563-25MG 25 mg
 $480.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to light brown
form powder
InChI 1S/C20H15F3N4O2/c1-11-17(12(2)28)18(13-6-7-15(9-24)25-10-13)26-19(29)27(11)16-5-3-4-14(8-16)20(21,22)23/h3-8,10,18H,1-2H3,(H,26,29)/t18-/m1/s1
InChI key PGIVGIFOWOVINL-GOSISDBHSA-N
optical activity [α]/D +21 to +29°, c = 0.5 in methanol
Quality Level 100 
SMILES string CC(N1C2=CC=CC(C(F)(F)F)=C2)=C(C(C)=O)[C@@H](C3=CN=C(C#N)C=C3)NC1=O
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: BAY-678 is an orally available, highly potent and selective inhibitor of human neutrophil elastase (HNE). For full characterization details, please visit the BAY-678 probe summary  on the Structural Genomics Consortium (SGC) website.

BAY-677 is used as a negative control and is available from Sigma. To learn more about and purchase BAY-677, click here .

To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc 
Biochem/physiol Actions: BAY-678 is an orally available, highly potent and selective inhibitor of human neutrophil elastase.
Features and Benefits: BAY-678 is a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC chemical probes, visit sigma.com/SGC .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 41106514

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