Leucinostatin A+B mixture
SIGMA/SML1566 - ≥95% (mixture of Leucinostatin A+B, HPLC), (Paecilomyces lilacinus)
Synonym: Antibiotic 1907-II; Antibiotic 1907-VIII; Leucinostatin A+B
Product Type: Chemical
| assay | ≥95% (mixture of Leucinostatin A+B, HPLC) |
| biological source | (Paecilomyces lilacinus) |
| form | powder |
| Quality Level | 200  |
| solubility | DMF: 10 mg/mL |
| DMSO: 10 mg/mL | |
| ethanol: 10 mg/mL | |
| methanol: 10 mg/mL | |
| storage temp. | −20°C |
| Biochem/physiol Actions: | Leucinostatins A and B are the major components of an atypical nonapeptide complex produced by Paecilomyces lilacinus. Leucinostatins display broad bio-activity against gram-positive bacteria, fungi, plants and tumor cell lines. They play a role as uncouplers in the inner mitochondria membrane and inhibit mitochondrial ATP synthesis. Recently, interest in Leucinostatins has focused on other aspects such as understanding their activity: insulin-like growth factor I regulators, ionophore, inhibitors of cell surface expression of viral glycoproteins and their potent in vitro and in vivo anti-trypanosomal activity. |
| Components: | Mixture of Leucinostatin A (Cas# 76600-38-9 / MF: C62H111N11O13) and Leucinostatin B (Cas# 76663-52-0 / MF: C61H109N11O13). |
| Other Notes: | Stable at −20 °C for at least 2 years. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Purity | ≥95% (mixture of Leucinostatin A+B, HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |
| Components | Leuconostatin A; Leucinostatin B |