MCB-613
SIGMA/SML1567 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 296792-62-6
Empirical Formula (Hill Notation): C20H20N2O
Molecular Weight: 304.39
Linear Formula: C20H20N2O
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| Quality Level | 100  |
| solubility | DMSO: 5 mg/mL, clear (warmed) |
| storage temp. | 2-8°C |
| Application: | MCB-613 has been used to study the molecular mechanism of MCB-613-induced cell death. |
| Biochem/physiol Actions: | MCB-613 is a pan-Steroid Receptor Coactivator (SRC) stimulator. There are three steroid receptor coactivators (SRC) that interact with transcription factors and whose overexpression is assciated with a number of cancers, particularly breast cancer. MCB-613 overstimulates SRC activity in cancer cells resulting in excessive generation of reactive oxygen species (ROS), leading to cell stress and death by a process called paraptosis. MCB-613 is a cytotoxic molecule which can kill various human cancer cell lines, like HepG2 (liver), PC-3 (prostate) and MCF-7 (breast) cells. |
| Biochem/physiol Actions: | MCB-613 is capable of inducing the transcriptional activity of steroid receptor coactivators (SRCs). |
| General description: | MCB-613 (4-Ethyl-2,6-bis-pyridin- |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 51111800 |