Arglabin

SIGMA/SML1570 - ≥98% (HPLC)

Synonym: (3aR,4aS,6aS,9aS,9bR)-5,6,6a,7,9a,9b-Hexahydro-1,4a-dimethyl-7-methylene-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one; 1(R),10(S)-Epoxy-5(S),5(S),7(S)-guaia-3(4),11(13)-dien-6,12-olide

CAS Number: 84692-91-1
Empirical Formula (Hill Notation): C₁₅H₁₈O₃
Molecular Weight: 246.30
Linear Formula: C₁₅H₁₈O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1570-1MG	1 mg	$101.00 1/EA	Add To Favorites
45-SML1570-5MG	5 mg	$408.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
biological source	semisynthetic (from parthenolide)
color	white to beige
form	powder
InChI	1S/C15H18O3/c1-8-4-7-15-11(8)12-10(9(2)13(16)17-12)5-6-14(15,3)18-15/h4,10-12H,2,5-7H2,1,3H3/t10-,11-,12-,14-,15+/m0/s1
InChI key	UVJYAKBJSGRTHA-ZCRGAIPPSA-N
Quality Level	100
SMILES string	O1[C@@]32[C@@]1(CC[C@@H]4[C@H](OC(=O)C4=C)[C@@H]3C(=CC2)C)C
storage condition	protect from light
storage temp.	−20°C

Biochem/physiol Actions:

Arglabin is a natural product with antitumor and anti-inflammatory activity. Arglabin competitively inhibits the binding of farnesyl diphosphate to farnesyl transferase (FTase), preventing the activation of RAS proto-oncogene by preventing the incorporation of farnesyl pyrophosphate into human H-ras proteins. Arglabin is also an inhibitor of the NLRP3 inflammasome. Arglabin reduces inflammation and plasma lipids and has shown a marked reduction in atherosclerotic lesions.

Packaging:

1, 5 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302 - H315 - H319 - H335
Precautionary statements	P301 + P312 + P330 - P305 + P351 + P338
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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