S14161

SIGMA/SML1571 - ≥98% (HPLC)

Synonym: 8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-1-benzopyran; 8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene; Pichromene

CAS Number: 883046-50-2
Empirical Formula (Hill Notation): C₁₇H₁₄FNO₄
Molecular Weight: 315.30
MDL Number: MFCD00112055
Linear Formula: C₁₇H₁₄FNO₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1571-1MG	1 mg	$80.70 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C17H14FNO4/c1-2-22-15-5-3-4-12-10-14(19(20)21)16(23-17(12)15)11-6-8-13(18)9-7-11/h3-10,16H,2H2,1H3
InChI key	BFZXDHIUPNWOMT-UHFFFAOYSA-N
Quality Level	100
SMILES string	FC(C=C1)=CC=C1C2C([N+]([O-])=O)=CC3=CC=CC(OCC)=C3O2
storage condition	desiccated
	protect from light
storage temp.	−20°C

Biochem/physiol Actions:

S14161 inhibits D-cyclin transactivation by inhibition of phosphoinositide 3-kinase (PI3K) activity. S14161 is a pan-class I PI3K inhibitor. S14161 inhibited the activity of all 4 isoforms of the PI3K class I family, and unlike LY294002, had little effect on class IV enzymes mechanistic target of rapamycin (mTOR) and DNA-PKcs (DNA-dependent protein kinase, catalytic subunit), or on AKT-1, -2, or -3 or PDK1. S14161 inhibited the expression of cyclins D1, D2, and D3, leading to the arrest of cells at the G0/G1 phase, and has exhibited anti-myeloma and anti-leukemia activity with no gross toxicity.

Packaging:

1, 5 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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