S14161
SIGMA/SML1571 - ≥98% (HPLC)
Synonym: 8-
CAS Number: 883046-50-2
Empirical Formula (Hill Notation): C17H14FNO4
Molecular Weight: 315.30
MDL Number: MFCD00112055
Linear Formula: C17H14FNO4
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C17H14FNO4/c1-2-22-15- |
InChI key | BFZXDHIUPNWOMT-UHFFFAOYSA |
Quality Level | 100 |
SMILES string | FC(C=C1)=CC=C1C2C([N+]([O |
storage condition | desiccated |
protect from light | |
storage temp. | −20°C |
Biochem/physiol Actions: | S14161 inhibits D-cyclin transactivation by inhibition of phosphoinositide 3-kinase (PI3K) activity. S14161 is a pan-class I PI3K inhibitor. S14161 inhibited the activity of all 4 isoforms of the PI3K class I family, and unlike LY294002, had little effect on class IV enzymes mechanistic target of rapamycin (mTOR) and DNA-PKcs (DNA-dependent protein kinase, catalytic subunit), or on AKT-1, -2, or -3 or PDK1. S14161 inhibited the expression of cyclins D1, D2, and D3, leading to the arrest of cells at the G0/G1 phase, and has exhibited anti-myeloma and anti-leukemia activity with no gross toxicity. |
Packaging: | 1, 5 mg in glass bottle |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H315 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |