Cyclosporin H
SIGMA/SML1575 - ≥97% (HPLC)
Synonym: 1,4,7,10,13,16,19,22,25,28,31-
CAS Number: 83602-39-5
Empirical Formula (Hill Notation): C62H111N11O12
Molecular Weight: 1202.61
Linear Formula: C62H111N11O12
Product Type: Chemical
assay | ≥97% (HPLC) |
biological source | Tolypocladium inflatum |
color | white to beige |
form | powder |
InChI | 1S/C63H113N11O12/c1-26-28 |
InChI key | BQQHPBPTWWXRMU-SXHXJWHLSA |
optical activity | [α]/D -100 to -115°, c = 0.5 in methanol |
Quality Level | 100 ![]() |
storage condition | desiccated |
protect from light | |
storage temp. | −20°C |
Application: | Cyclosporin H has been used: • to pre-culture the lineage depleted murine Flt3ITDIDH2R140Q BM cells for transduction • as a formyl peptide receptor (FPR) antagonist to study the role of FPR1 in calcium mobilization in polymorphonuclear leukocytes (PMNs) • as one of the small molecules to study its effect on the homology-directed repair (HDR) editing efficiency in human-induced pluripotent stem cells (iPSCs) and T cells |
Biochem/physiol Actions: | Cyclosporin H is a selective inhibitor of formyl peptide receptor-1 (FPR-1) and formyl peptide-induced superoxide formation in neutrophils. Cyclosporin H does not bind cyclophilin or evoke an immunosuppressant response. Cyclosporin H has been reported to inhibit tumor promoting phorbol ester TPA/PMA in mouse skin cells and to inhibit calcium/calmodulin-depend |
Packaging: | 1, 5 mg in glass bottle |
Symbol | ![]() ![]() |
Signal word | Danger |
Hazard statements | H302 - H350 - H360 |
Precautionary statements | P201 - P301 + P312 + P330 - P308 + P313 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥97% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |