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Aftin-4

SIGMA/SML1578 - ≥98% (HPLC)

Synonym: (2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol; Amyloid-β Forty-Two Inducer 4; N6-Methyl-(R)-roscovitine

CAS Number: 866893-90-5
Empirical Formula (Hill Notation): C20H28N6O
Molecular Weight: 368.48
Linear Formula: C20H28N6O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1578-5MG 5 mg
 $204.00
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45-SML1578-25MG 25 mg
 $613.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C20H28N6O/c1-5-16(12-27)22-20-23-18(25(4)11-15-9-7-6-8-10-15)17-19(24-20)26(13-21-17)14(2)3/h6-10,13-14,16,27H,5,11-12H2,1-4H3,(H,22,23,24)/t16-/m1/s1
InChI key YPYWONAECUVKHY-MRXNPFEDSA-N
Quality Level 100 
SMILES string [n]1(c2nc(nc(c2nc1)N(Cc3ccccc3)C)N[C@@H](CO)CC)C(C)C
solubility DMSO: 25 mg/mL, clear
storage condition protect from light
storage temp. −20°C
Biochem/physiol Actions: Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer′s disease-like toxicity in the rodent brain.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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