BMS-3
SIGMA/SML1582 - ≥95% (HPLC)
Synonym: N-
CAS Number: 1338247-30-5
Empirical Formula (Hill Notation): C17H12Cl2F2N4OS
Molecular Weight: 429.27
Linear Formula: C17H12Cl2F2N4OS
Product Type: Chemical
assay | ≥95% (HPLC) |
color | white to light brown |
form | powder |
Quality Level | 100 ![]() |
solubility | DMSO: 10 mg/mL, clear |
storage temp. | −20°C |
Biochem/physiol Actions: | BMS-3 shows cytotoxic effects not related to LIMK, but rather through reduction of the levels of tubulin transcripts and induction of mitotic arrest. |
Biochem/physiol Actions: | It is a specific inhibitor of LIMK1. LIMK1 is responsible for the inactivation of cofilin (ADF family protein), leading to actin reorganization. It is upregulated in several invasive cancers. |
General description: | LIMK1 (LIM domain kinase 1) belongs to the serine-threonine protein kinases. The gene is mapped to human chromosome 7q11. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H302 - H413 |
Precautionary statements | P301 + P312 + P330 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |