Synonym: 2,2,2-trifluoroacetate; Cyclo(L-arginylglycyl-L-a-aspartyl-D-phenylalanyl-N-methyl-L-valyl), 2,2,2-trifluoroacetate; EMD 121974; NSC 707544; c(RGDF(NMe)V)
CAS Number: 188968-51-6 (free base)
Empirical Formula (Hill Notation): C27H40N8O7 · xC2HF3O2
Molecular Weight: 588.66 (free base basis)
Linear Formula: C27H40N8O7 · xC2HF3O2
Product Type: Chemical
| assay |
≥95% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C27H40N8O7/c1-15(2)22-25(41)33-17(10-7-11-30-27(28)29)23(39)31-14-20(36)32-18(13-21(37)38)24(40)34-19(26(42)35(22)3)12-16-8-5-4-6-9-16/h4-6,8-9,15,17-19,22H,7,10-14H2,1-3H3,(H,31,39)(H,32,36)(H,33,41)(H,34,40)(H,37,38)(H4,28,29,30)/t17-,18-,19+,22-/m0/s1 |
| InChI key |
AMLYAMJWYAIXIA-VWNVYAMZSA-N |
| Quality Level |
100  |
| solubility |
H2O: 20 mg/mL, clear |
| storage temp. |
−20°C |
| Application: |
Cilengitide trifluoroacetic acid salt has been used as an inhibitor of integrin αvβ5. |
| Biochem/physiol Actions: |
Cilengitide is a vascular targeting agent (VTA) that acts as an integrin antagonist. Cilengitide is a cyclized Arg-Gly-Glu(RGD)-containing pentapeptide that selectively blocks activation of the αvβ3 and αvβ5 integrins. |
| Biochem/physiol Actions: |
It exhibits antitumor activity in glioblastoma multiforme tumors. Integrins are heterodimers of α and β chain. They are transmembrane receptors which are responsible for cell-to-cell and cell-extracellular matrix interactions. They control tumor angiogenesis, invasion and migration. |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Purity |
≥95% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352106 |
