PPZ2
SIGMA/SML1596 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 896203-18-2
Empirical Formula (Hill Notation): C22H29N3O2
Molecular Weight: 367.48
Linear Formula: C22H29N3O2
Product Type: Chemical
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This image depicts SML1596-5MG.
This image depicts SML1596-5MG.
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| Quality Level | 100  |
| solubility | DMSO: 5 mg/mL, clear (warmed) |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | PPZ2 is an activator of DAG-activated TRPC3/TRPC6/TRPC7 channels. Neurotrophic. |
| Biochem/physiol Actions: | PPZ2 selectively activates DAG-activated TRPC3/TRPC6/TRPC7 channels. PPZ2 activates native TRPC6-like channels in smooth muscle cells isolated from the rabbit portal vein. PPZ2 induces BDNF-like neurite growth and neuroprotection in cultured neurons. |
| Biochem/physiol Actions: | TRPCs are cation channels, mainly permeable to Ca2+ ions. TRPC6 plays a crucial role in tumor development. TRPC3 controls fibronectin expression, thereby regulating wound healing process. TRPC7 is involved in the proliferation of osteoblasts. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |