VR23

SIGMA/SML1599 - ≥98% (HPLC)

Synonym: 7-Chloro-4-(4-(2,4-dinitrophenylsulfonyl)piperazin-1-yl)quinoline; 7-Chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]-quinoline; VR-23

CAS Number: 1624602-30-7
Empirical Formula (Hill Notation): C₁₉H₁₆ClN₅O₆S
Molecular Weight: 477.88
Linear Formula: C₁₉H₁₆ClN₅O₆S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1599-5MG	5 mg	$125.00 1/EA	Add To Favorites

This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C19H16ClN5O6S/c20-13-1-3-15-16(11-13)21-6-5-17(15)22-7-9-23(10-8-22)32(30,31)19-4-2-14(24(26)27)12-18(19)25(28)29/h1-6,11-12H,7-10H2
InChI key	PDQVZPPIHADUOO-UHFFFAOYSA-N
Quality Level	100
SMILES string	[S](=O)(=O)(N2CCN(CC2)c3c4c(ncc3)cc(cc4)Cl)c1c(cc(cc1)[N+](=O)[O-])[N+](=O)[O-]
solubility	DMSO: 20 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	Potent inhibitor of proteasome that primary targets β2 of the 20S proteasome catalytic subunit
Biochem/physiol Actions:	Proteasomes are responsible for the cleavage of peptides in an ATP/ubiquitin-dependent manner.
Biochem/physiol Actions:	VR23 is a potent inhibitor of proteasome that primary targets β2 of the 20S proteasome catalytic subunit. VR23 selectively induces apoptosis to cancer cells via cyclin E–mediated centrosome amplification. VR23 exhibit little effect on noncancerous cells.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P301 + P312 + P330
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

To Order From a Quote