VR23
SIGMA/SML1599 - ≥98% (HPLC)
Synonym: 7-
CAS Number: 1624602-30-7
Empirical Formula (Hill Notation): C19H16ClN5O6S
Molecular Weight: 477.88
Linear Formula: C19H16ClN5O6S
Product Type: Chemical
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This image depicts SML1599-5MG.
This image depicts SML1599-5MG.
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C19H16ClN5O6S/c20-13-1 |
| InChI key | PDQVZPPIHADUOO-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | [S](=O)(=O)(N2CCN(CC2)c3c |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | Potent inhibitor of proteasome that primary targets β2 of the 20S proteasome catalytic subunit |
| Biochem/physiol Actions: | Proteasomes are responsible for the cleavage of peptides in an ATP/ubiquitin-dependent manner. |
| Biochem/physiol Actions: | VR23 is a potent inhibitor of proteasome that primary targets β2 of the 20S proteasome catalytic subunit. VR23 selectively induces apoptosis to cancer cells via cyclin E–mediated centrosome amplification. VR23 exhibit little effect on noncancerous cells. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301 + P312 + P330 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |