OTX015

SIGMA/SML1605 - ≥98% (HPLC)

Synonym: 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-, (6S)-; OTX-015

CAS Number: 202590-98-5
Empirical Formula (Hill Notation): C₂₅H₂₂ClN₅O₂S
Molecular Weight: 491.99
MDL Number: MFCD26960949
Linear Formula: C₂₅H₂₂ClN₅O₂S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1605-5MG	5 mg	$269.00 1/EA	Add To Favorites
45-SML1605-25MG	25 mg	$1050.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to light brown
form	powder
InChI	1S/C25H22ClN5O2S/c1-13-14(2)34-25-22(13)23(16-4-6-17(26)7-5-16)28-20(24-30-29-15(3)31(24)25)12-21(33)27-18-8-10-19(32)11-9-18/h4-11,20,32H,12H2,1-3H3,(H,27,33)/t20-/m0/s1
InChI key	GNMUEVRJHCWKTO-FQEVSTJZSA-N
Quality Level	100
SMILES string	O=C(NC(C=C1)=CC=C1O)C[C@H]2C3=NN=C(C)N3C(SC(C)=C4C)=C4C(C5=CC=C(Cl)C=C5)=N2
solubility	DMSO: 20 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	It binds to bromodomain and extra-terminal domain (BET) proteins and inhibits their binding to the chromatin. This in turn prevents gene transcription. OTX015 has been shown to inhibit proliferation of cells in haematological malignancies.
Biochem/physiol Actions:	OTX015 is a potent inhibitor of the BET bromodomain proteins 2, 3, and 4 (BRD2/3/4).
Biochem/physiol Actions:	OTX015 is a potent inhibitor of the BET bromodomain proteins 2, 3, and 4.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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