Besifloxacin hydrochloride
SIGMA/SML1608 - ≥98% (HPLC)
Synonym: 7-
CAS Number: 1398566-43-2
Empirical Formula (Hill Notation): C19H21ClFN3O3 · HCl
Molecular Weight: 430.30
MDL Number: MFCD23712955
Linear Formula: C19H21ClFN3O3 · HCl
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to light brown |
| form | powder |
| Quality Level | 100  |
| SMILES string | [H]Cl.OC(C1=CN(C2CC2)C3=C |
| solubility | DMSO: 2 mg/mL, clear (warmed) |
| storage condition | desiccated |
| storage temp. | −20°C |
| Biochem/physiol Actions: | Besifloxacin is a broad spectrum fourth-generation fluoroquinolone antibiotic. |
| Biochem/physiol Actions: | Besifloxacin is a broad spectrum fourth-generation fluoroquinolone antibiotic. Besifloxacin is effective against gram positive and negative, aerobic and anerobic bacteria. Fluoroquinolones stabilize DNA strand breaks created by DNA gyrase and topoisomerase IV by binding to the enzyme-DNA complex generating persistent, covalent enzyme–DNA adducts, inhibiting DNA synthesis. Besifloxacin inhibits both DNA gyrase and topoisomerase IV at nearly equal concentrations. It is used clinically primarily in the treatment of bacterial conjunctivitis. |
| Biochem/physiol Actions: | Besifloxacin stops the production of pro-inflammatory cytokines in vitro. |
| Packaging: | 10, 50 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 |
| Precautionary statements | P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |