Synonym: 1-[5-(1H-1,2,4-Triazol-5-yl)-1H-indazol-3-yl]-3-(2-piperidinoethoxy)benzene dihydrochloride; 3-(3-(2-(Piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-3-yl)-1H-indazole dihydrochloride; 3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-iIndazole dihydrochloride; CC 401; CC401; CID 10430360
CAS Number: 1438391-30-0
Empirical Formula (Hill Notation): C22H24N6O · 2HCl
Molecular Weight: 461.39
MDL Number: MFCD21364765
Linear Formula: C22H24N6O · 2HCl
Product Type: Chemical
| assay |
≥95% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C22H24N6O.ClH/c1-2-9-28(10-3-1)11-12-29-18-6-4-5-16(13-18)21-19-14-17(22-23-15-24-27-22)7-8-20(19)25-26-21;/h4-8,13-15H,1-3,9-12H2,(H,25,26)(H,23,24,27);1H |
| InChI key |
OIBVXKYKWOUGAO-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
[H]Cl.C1(C2=NC=NN2)=CC3=C(NN=C3C4=CC=CC(OCCN5CCCCC5)=C4)C=C1 |
| solubility |
H2O: 10 mg/mL, clear |
| storage temp. |
−20°C |
| Biochem/physiol Actions: |
CC-401 is a cell penetrant, potent and selective c-Jun N terminal kinase (JNK) inhibitor that blocks JNK signaling in the rat obstructed kidney and inhibits renal fibrosis in the unilateral ureteral obstruction model. CC-401 in combination with chemotherapy exhibits synergism in colon cancer cell lines. |
| Biochem/physiol Actions: |
CC-401 is a cell penetrant, potent and selective c-Jun N terminal kinase (JNK) inhibitor. |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥95% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
