SEN177
SIGMA/SML1615 - ≥98% (HPLC)
Synonym: 6′′-Fluoro-4-(4-methyl-4H-[1,2,4]triazol-3-yl)-3,4,5,6-tetrahydro-2H-[1,2′;3′,3′′]terpyridine
CAS Number: 2117405-13-5
Empirical Formula (Hill Notation): C18H19FN6
Molecular Weight: 338.38
Linear Formula: C18H19FN6
Product Type: Chemical
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1615-5MG.
This image depicts SML1615-5MG.
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C18H19FN6/c1-24-12-22- |
| InChI key | AJIAMIPUWJQSPR-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | FC(C=C1)=NC=C1C2=CC=CN=C2 |
| solubility | DMSO: 10 mg/mL, clear |
| storage temp. | −20°C |
| Biochem/physiol Actions: | SEN177 is a Glutaminyl cyclase (QPCT) inhibitor. |
| Biochem/physiol Actions: | SEN177 is a Glutaminyl cyclase (QPCT) inhibitor. Glutaminyl cyclase modifies N-terminal glutamine or glutamate residues to N-terminal 5-oxoproline or pyroglutamate (named QPCT). QPCT inhibits mutant huntingtin from forming aggregates, but also reduces aggregation of other aggregate-prone proteins containing polyQ or polyA repeats. SEN177 caused dose-dependent decreases in HTT aggregation by a mechanism that requires QPCT inhibition. SEN177 had in vitro activity against polyglutamine toxicity and was able to reduce aggregates in mammalian cells, primary neurons and in a Drosophila model. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301 + P330 + P331 + P310 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |