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GSK2033

SIGMA/SML1617 - ≥98% (HPLC)

Synonym: 2,4,6-Trimethyl-N-[[3′-(methylsulfonyl)[1,1′-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]benzenesulfonamide

CAS Number: 1221277-90-2
Empirical Formula (Hill Notation): C29H28F3NO5S2
Molecular Weight: 591.66
MDL Number: MFCD28396416
Linear Formula: C29H28F3NO5S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1617-5MG 5 mg
 $180.00
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45-SML1617-25MG 25 mg
 $722.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1617-25MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C29H28F3NO5S2/c1-19-14-20(2)28(21(3)15-19)40(36,37)33(18-25-12-13-27(38-25)29(30,31)32)17-22-8-10-23(11-9-22)24-6-5-7-26(16-24)39(4,34)35/h5-16H,17-18H2,1-4H3
InChI key PSOXOVKYGWBTPB-UHFFFAOYSA-N
Quality Level 100 
SMILES string CS(C1=CC=CC(C2=CC=C(CN(S(C3=C(C)C=C(C)C=C3C)(=O)=O)CC4=CC=C(C(F)(F)F)O4)C=C2)=C1)(=O)=O
solubility DMSO: 3 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: GSK2033 has the ability to repress gluconeogenic gene expression stimulated by GC (glucocorticoids), without altering immune-responsive GR (GC receptor) target genes. It helps to target several nuclear receptors that can alter hepatic gene expression.
Biochem/physiol Actions: GSK2033 is an antagonist of the nuclear receptor liver-X-receptor (LXR) with pIC50 values of 7.0 for LXRα and 7.4 for LXRβ. Treatment of murine CD41 T cells with GSK2033 enhanced cellular proliferation and Th1/Th2/Th17 differentiation. In another study, the conjugated linoleic acid (CLA)-induced expression of efflux protein ATP-binding-cassette transporter A1 (ABCA1) was completely abolished by preincubation with GSK2033, showing that CLA mediated regulation of ABCA-1 expression is LXR dependent.
Biochem/physiol Actions: LXR antagonist
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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