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GSK2033

SIGMA/SML1617 - ≥98% (HPLC)

Synonym: 2,4,6-Trimethyl-N-[[3′-(methylsulfonyl)[1,1′-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]benzenesulfonamide

CAS Number: 1221277-90-2
Empirical Formula (Hill Notation): C29H28F3NO5S2
Molecular Weight: 591.66
MDL Number: MFCD28396416
Linear Formula: C29H28F3NO5S2
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-SML1617-5MG 5 mg
$163.00
1/EA
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45-SML1617-25MG 25 mg
$655.00
1/EA
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C29H28F3NO5S2/c1-19-14-20(2)28(21(3)15-19)40(36,37)33(18-25-12-13-27(38-25)29(30,31)32)17-22-8-10-23(11-9-22)24-6-5-7-26(16-24)39(4,34)35/h5-16H,17-18H2,1-4H3
InChI key PSOXOVKYGWBTPB-UHFFFAOYSA-N
Quality Level 100 
SMILES string CS(C1=CC=CC(C2=CC=C(CN(S(C3=C(C)C=C(C)C=C3C)(=O)=O)CC4=CC=C(C(F)(F)F)O4)C=C2)=C1)(=O)=O
solubility DMSO: 3 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: GSK2033 has the ability to repress gluconeogenic gene expression stimulated by GC (glucocorticoids), without altering immune-responsive GR (GC receptor) target genes. It helps to target several nuclear receptors that can alter hepatic gene expression.
Biochem/physiol Actions: GSK2033 is an antagonist of the nuclear receptor liver-X-receptor (LXR) with pIC50 values of 7.0 for LXRα and 7.4 for LXRβ. Treatment of murine CD41 T cells with GSK2033 enhanced cellular proliferation and Th1/Th2/Th17 differentiation. In another study, the conjugated linoleic acid (CLA)-induced expression of efflux protein ATP-binding-cassette transporter A1 (ABCA1) was completely abolished by preincubation with GSK2033, showing that CLA mediated regulation of ABCA-1 expression is LXR dependent.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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