Synonym: 1-Cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid methane sulfonic acid salt monohydrate; BMS 284756 mesylate; Ganefloxacin mesylate; Garenfloxacin mesylate; T-3811 mesylate
CAS Number: 223652-90-2
Empirical Formula (Hill Notation): C23H20F2N2O4 · CH4O3S · H2O
Molecular Weight: 540.53
MDL Number: MFCD12031996
Linear Formula: C23H20F2N2O4 · CH4O3S · H2O
Product Type: Chemical
assay |
≥98% (HPLC) |
color |
white to beige |
form |
powder |
InChI |
1S/C23H20F2N2O4.CH4O3S.H2O/c1-11-15-5-2-12(8-13(15)9-26-11)16-6-7-17-19(21(16)31-23(24)25)27(14-3-4-14)10-18(20(17)28)22(29)30;1-5(2,3)4;/h2,5-8,10-11,14,23,26H,3-4,9H2,1H3,(H,29,30);1H3,(H,2,3,4);1H2/t11-;;/m1../s1 |
InChI key |
IGTHEWGRXUAFKF-NVJADKKVSA-N |
Quality Level |
100 |
SMILES string |
OC(C1=CN(C2CC2)C3=C(OC(F)F)C(C4=CC(CN[C@@H]5C)=C5C=C4)=CC=C3C1=O)=O.CS(=O)(O)=O.[H]O[H] |
solubility |
H2O: 10 mg/mL, clear (warmed) |
storage condition |
desiccated |
storage temp. |
2-8°C |
Biochem/physiol Actions: |
Garenoxacin is a broad spectrum fluoroquinolone antibiotic suitable for treatment of gram-positive and gram-negative bacterial infections. Garenoxacin has a low mutant prevention concentration and a narrow mutant selection window. Data shows that garenoxacin has anti-inflammatory properties. It significantly alleviates LPS-induced IL-8 production through the negative regulation of the ERK1/2 pathway both in the human airway epithelial cell line A549 and the monocyte cell line THP-1. |
Packaging: |
10, 50 mg in glass bottle |
RIDADR |
NONH for all modes of transport |
WGK Germany |
WGK 3 |
Purity |
≥98% (HPLC) |
Storage Temp. |
2-8°C |
UNSPSC |
12352200 |