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OSMI-1

SIGMA/SML1621 - ≥98% (HPLC)

Synonym: (αR)-α-[[(1,2-Dihydro-2-oxo-6-quinolinyl)sulfonyl]amino]-N-(2-furanylmethyl)-2-methoxy-N-(2-thienylmethyl)-benzeneacetamide; OSMI 1

CAS Number: 1681056-61-0
Empirical Formula (Hill Notation): C28H25N3O6S2
Molecular Weight: 563.64
Linear Formula: C28H25N3O6S2
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-SML1621-5MG 5 mg
$177.00
1/EA
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45-SML1621-25MG 25 mg
$707.00
1/EA
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C28H25N3O6S2/c1-36-25-9-3-2-8-23(25)27(28(33)31(17-20-6-4-14-37-20)18-21-7-5-15-38-21)30-39(34,35)22-11-12-24-19(16-22)10-13-26(32)29-24/h2-16,27,30H,17-18H2,1H3,(H,29,32)/t27-/m1/s1
InChI key IYIGLWQQAMROOF-HHHXNRCGSA-N
Quality Level 100 
SMILES string O=C(N1)C=CC2=C1C=CC(S(N[C@H](C3=C(OC)C=CC=C3)C(N(CC4=CC=CS4)CC5=CC=CO5)=O)(=O)=O)=C2
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Application: OSMI-1 (OGT with a small molecule inhibitor) has been used in proximal ligation assay, Sox2 (SRY (sex determining region Y)-Box 2 ) dual luciferase reporter assay, Sox2 ELISA (enzyme linked immunosorbent assay) and other in vivo approaches, to study the O-Linked β-N-acetylglucosamine (O-GlcNAc) mediated regulation of self-renewal genes in cancer. It has also been used to study the Hippo pathway regulation mediated by O-GlcNAc transferase.
Biochem/physiol Actions: OGT catalyses the attachment of N-acetylglucosamine moieties to a number proteins during post-translational modification. Inhibition of OGT activity might hinder the rate of viral replication in infections such as Herpes simplex viral disease.
Biochem/physiol Actions: OSMI-1 is a cell permeable inhibitor of OGT (O-GlcNAc transferase).
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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