LMT-28
SIGMA/SML1628 - ≥98% (HPLC)
Synonym: (4S)
CAS Number: 1239600-18-0
Empirical Formula (Hill Notation): C17H29NO4
Molecular Weight: 311.42
Linear Formula: C17H29NO4
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | colorless to light yellow, oil |
| form | oil |
| InChI | 1S/C17H29NO4/c1-6-7-8-9-1 |
| InChI key | UDXWSYOXIRPYFK-RRFJBIMHSA |
| Quality Level | 100  |
| shipped in | wet ice |
| SMILES string | CC(C)[C@H](N1C([C@@H](C)[ |
| storage temp. | −20°C |
| Biochem/physiol Actions: | LMT-28 is a derivative of oxazolidinone. It has the ability to repress the activation of signal transducer and activator of transcription 3 (STAT3) stimulated by interleukin 6 (IL-6). Orally administered LMT-28 reduced arthritis and acute pancreatitis stimulated by collagen in mice pathologic models. |
| Biochem/physiol Actions: | LMT-28 is an IL-6 antagonist that targets the IL-6 Receptor β subunit, Glycoprotein 130 (gp130). Its binding to gp130) results in inhibition of IL-6 activation, and downregulation of levels of p-STAT3. LMT-28 was shown to stimulate phosphorylation of STAT3 and JAK2 protein. IL-6 dysregulation is involved in inflammation and cancers. LMT-28 had inhbitory activity against IL-6–dependent TF-1 cell proliferation and also had therapeutic effect against pancreatitis. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |