Ezetimibe
SIGMA/SML1629 - ≥98% (HPLC)
Synonym: (3R,4S)
CAS Number: 163222-33-1
Empirical Formula (Hill Notation): C24H21F2NO3
Molecular Weight: 409.43
MDL Number: MFCD00937872
Linear Formula: C24H21F2NO3
Product Type: Chemical
assay | ≥98% (HPLC) |
form | powder |
InChI | 1S/C24H21F2NO3/c25-17-5-1 |
InChI key | OLNTVTPDXPETLC-XPWALMASSA |
Quality Level | 200 ![]() |
SMILES string | FC(C=C1)=CC=C1N([C@H](C2= |
solubility | DMF: soluble ≥15 mg/mL |
DMSO: soluble ≥15 mg/mL | |
ethanol: soluble ≥15 mg/mL | |
methanol: soluble ≥15 mg/mL | |
storage temp. | 2-8°C |
Biochem/physiol Actions: | Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by Niemann-Pick C1 Like 1 (NPC1L1) protein that was found critical for the intestinal absorption of cholesterol. Ezetimibe selectvely blocks cholesterol absorption without inhibiting pancreatic lipolytic enzyme activities in the intestinal lumen. |
Biochem/physiol Actions: | Ezetimibe is a non statin drug that reduces intestinal cholesterol absorption. In addition, it also has an ability to reduce the risk of cardiovascular events in patients who had had an acute coronary syndrome and whose low-density lipoprotein (LDL) cholesterol values were within guideline recommendations. |
Reconstitution: | For solubility in aqueous buffer, Ezetimibe should be dissolved in ethanol followed by dilution with the buffer. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |