Ezetimibe

SIGMA/SML1629 - ≥98% (HPLC)

Synonym: (3R,4S)-1-(4-Fluorophenyl)-3-[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one

CAS Number: 163222-33-1
Empirical Formula (Hill Notation): C₂₄H₂₁F₂NO₃
Molecular Weight: 409.43
MDL Number: MFCD00937872
Linear Formula: C₂₄H₂₁F₂NO₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1629-25MG	25 mg	$145.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
form	powder
InChI	1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1
InChI key	OLNTVTPDXPETLC-XPWALMASSA-N
Quality Level	200
SMILES string	FC(C=C1)=CC=C1N([C@H](C2=CC=C(O)C=C2)[C@H]3CC[C@H](O)C4=CC=C(F)C=C4)C3=O
solubility	DMF: soluble ≥15 mg/mL
	DMSO: soluble ≥15 mg/mL
	ethanol: soluble ≥15 mg/mL
	methanol: soluble ≥15 mg/mL
storage temp.	2-8°C

Biochem/physiol Actions:	Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by Niemann-Pick C1 Like 1 (NPC1L1) protein that was found critical for the intestinal absorption of cholesterol. Ezetimibe selectvely blocks cholesterol absorption without inhibiting pancreatic lipolytic enzyme activities in the intestinal lumen.
Biochem/physiol Actions:	Ezetimibe is a non statin drug that reduces intestinal cholesterol absorption. In addition, it also has an ability to reduce the risk of cardiovascular events in patients who had had an acute coronary syndrome and whose low-density lipoprotein (LDL) cholesterol values were within guideline recommendations.
Preparation Note:	For solubility in aqueous buffer, Ezetimibe should be dissolved in ethanol followed by dilution with the buffer.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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