Hexaminolevulinate hydrochloride
SIGMA/SML1637 - ≥98% (HPLC)
Synonym: 5-Aminolevulinic acid hexyl ester HAL hydrochloride; 5-Aminolevulinic acid hexyl ester hydrochloride; HAL; Hexvix; Hexyl 5-aminolevulinate hydrochloride; P 1206; n-Hexyl 5-aminolevulinate hydrochloride
CAS Number: 140898-91-5
Empirical Formula (Hill Notation): C11H21NO3 · HCl
Molecular Weight: 251.75
MDL Number: MFCD03695491
Linear Formula: C11H21NO3 · HCl
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C11H21NO3.ClH/c1-2-3-4 |
InChI key | LZYXPFZBAZTOCH-UHFFFAOYSA |
Quality Level | 100 |
SMILES string | CCCCCCOC(CCC(CN)=O)=O.[H] |
solubility | H2O: 20 mg/mL, clear |
storage condition | desiccated |
storage temp. | room temp |
Biochem/physiol Actions: | Hexaminolevulinate (HAL) hydrochloride is a hexyl ester of 5-Aminolevulinic acid (ALA), a precursor to porphyrins including the photosensitizer protoporphyrin IX (PPIX). Hexaminolevulinate is more lipophilic than ALA, and is 50–100 times more efficient than ALA at inducing PpIX, which accumulates preferentially in neoplastic cells. Hexaminolevulinate administration followed by light activation has been used for fluorescence cystoscopy to enhance detection of bladder cancer, in particular carcinoma in situ (CIS). Hexaminolevulinate is also being studied for use in cancer photodynamic therapy. Hexaminolevulinate followed by irradiation produced DNA oxidative damage and apoptosis. |
Packaging: | 10, 50 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Purity | ≥98% (HPLC) |
Storage Temp. | room temp |
UNSPSC | 12352200 |