Advanced Search



VX-745

SIGMA/SML1638 - ≥98% (HPLC)

Synonym: 5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one

CAS Number: 209410-46-8
Empirical Formula (Hill Notation): C19H9Cl2F2N3OS
Molecular Weight: 436.26
MDL Number: MFCD09834070
Linear Formula: C19H9Cl2F2N3OS
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1638-5MG 5 mg
 $119.00
1/EA		 Add To Favorites
45-SML1638-25MG 25 mg
 $480.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1638-25MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H
InChI key VEPKQEUBKLEPRA-UHFFFAOYSA-N
Quality Level 100 
SMILES string FC1=C(SC2=NN(C=N3)C(C=C2)=C(C4=C(Cl)C=CC=C4Cl)C3=O)C=CC(F)=C1
solubility DMSO: 10 mg/mL, clear
storage temp. −20°C
Biochem/physiol Actions: VX-745 is a selective blood-brain barrier penetrant inhibitor of p38 MAPKα.
Biochem/physiol Actions: VX-745 is a selective blood-brain barrier penetrant inhibitor of p38 MAPKα. VX-745 showed 20-fold selectivity for p38α over p38β and a Ki value of 220 nM. VX-745 has been shown to reduce inflammation in an arthritic (AIA) mouse model and to improve performance in aged rats.
Other Notes: VX-745 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the VX-745 probe summary  on the Chemical Probes Portal website.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

The following items have been added to your cart:

Choose a favorite list for this item:
Catalog Number Description Price
$

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.


Quick Order

* Required


New Year Price Updates

We are currently working diligently to update our website pricing information for the New Year. If you place an order, you will be acknowledged with any corrected pricing. If you'd like the most current information sooner, please don't hesitate to drop us an email or give us a call and we'd be happy to assist. Thank you for your patience while we are updating.

800-334-7725
office@krackeler.com


Play Video

To Request a Quote

  1. Search or Browse for items and add to them to your Shopping Cart.
  2. Click the "Request Quote" button at the bottom of the Shopping Cart page.
  3. Fill out required fields.
  4. Optionally you can convert to standard checkout mode by choosing a payment type.
  5. Click "Request Quote" at the bottom of the page.

You will be contacted with a quote.

To Order From a Quote

  1. Register and login to the website.
  2. Receive a quote from your sales representative or customer service.
  3. Have your copy of the quote in hand.
  4. Visit our quote module to search for your quote.
Back to Top