VX-745
SIGMA/SML1638 - ≥98% (HPLC)
Synonym: 5-
CAS Number: 209410-46-8
Empirical Formula (Hill Notation): C19H9Cl2F2N3OS
Molecular Weight: 436.26
MDL Number: MFCD09834070
Linear Formula: C19H9Cl2F2N3OS
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C19H9Cl2F2N3OS/c20-11- |
InChI key | VEPKQEUBKLEPRA-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | FC1=C(SC2=NN(C=N3)C(C=C2) |
solubility | DMSO: 10 mg/mL, clear |
storage temp. | −20°C |
Biochem/physiol Actions: | VX-745 is a selective blood-brain barrier penetrant inhibitor of p38 MAPKα. VX-745 showed 20-fold selectivity for p38α over p38β and a Ki value of 220 nM. VX-745 has been shown to reduce inflammation in an arthritic (AIA) mouse model and to improve performance in aged rats. |
Other Notes: | VX-745 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the VX-745 probe summary ![]() ![]() |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |