BRD3308

SIGMA/SML1639 - ≥98% (HPLC)

Synonym: 4-Acetamido-N-(2-amino-4-fluorophenyl)benzamide

CAS Number: 1550053-02-5
Empirical Formula (Hill Notation): C₁₅H₁₄FN₃O₂
Molecular Weight: 287.29
Linear Formula: C₁₅H₁₄FN₃O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1639-5MG	5 mg	$165.00 1/EA		Add To Favorites
45-SML1639-25MG	25 mg	$660.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C15H14FN3O2/c1-9(20)18-12-5-2-10(3-6-12)15(21)19-14-7-4-11(16)8-13(14)17/h2-8H,17H2,1H3,(H,18,20)(H,19,21)
InChI key	RRJDFENBXIEAPD-UHFFFAOYSA-N
Quality Level	100
SMILES string	CC(NC1=CC=C(C(NC2=CC=C(F)C=C2N)=O)C=C1)=O
solubility	DMSO: 10 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	BRD3308 is a highly selective inhibitor of histone deacetylase 3 (HDAC3) with an IC₅₀ value of 65 nM for HDAC3 vs. IC₅₀ values of 1.08 μM and 1.15 μM for HDAC1 and HDAC2, respectively. BRD3308 protected pancreatic β cells, suppressing inflammatory cytokine-induced apoptosis and increasing insulin release without the toxicity associated with HDAC1 and HDAC2 inhibitors. In a rat model of type 2 diabetes, BRD3308 reduced hyperglycemia and increased insulin secretion without affecting weight gain. In another study, BRD3308 was found to activate HIV-1 transcription, disrupting HIV-1 latency.
Biochem/physiol Actions:	BRD3308 is a highly selective inhibitor of histone deacetylase 3 (HDAC3).
Biochem/physiol Actions:	BRD3308 promotes outgrowth of HIV-1 (human immunodeficiency virus 1) from inactive infected patient cells. It helps to increase β-cell proliferation.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319
Precautionary statements	P305 + P351 + P338
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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