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DHED

SIGMA/SML1642 - ≥98% (HPLC)

Synonym: (17β)-10,17-Dihydroxy-estra-1,4-dien-3-one; 10β,17β-Dihydroxyestra-1,4-dien-3-one; 3,16-Dihydroxyandrost-5-ene-17,19-dione

CAS Number: 549-02-0
Empirical Formula (Hill Notation): C18H24O3
Molecular Weight: 288.38
Linear Formula: C18H24O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1642-5MG 5 mg
 $119.00
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45-SML1642-25MG 25 mg
 $480.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1642-25MG.

 

assay ≥98% (HPLC)
color white to light brown
form powder
InChI 1S/C18H24O3/c1-17-8-7-15-13(14(17)4-5-16(17)20)3-2-11-10-12(19)6-9-18(11,15)21/h6,9-10,13-16,20-21H,2-5,7-8H2,1H3/t13-,14-,15-,16-,17-,18+/m0/s1
InChI key UIKDFTLKOKNUJP-UGDFAFBOSA-N
optical activity [α]/D -20 to -30°, c = 1 in methanol
Quality Level 100 
SMILES string O[C@@]12C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4O)=CC(C=C1)=O
solubility DMSO: 10 mg/mL, clear
storage temp. 2-8°C
Application: DHED has been used to induce an increase of estrogen levels in 3K transgenic mice with Parkinson′s disease (PD)-like motor syndrome.
Biochem/physiol Actions: DHED (10β,17β-dihydroxyestra-1,4-dien-3-one) is an inactive prodrug that selectively produces estrogen solely in the brain. DHED is converted to 17β-estradiol in the brain by an enzyme only expressed in the CNS, but is inert in the rest of the body. DHED was found to provide neuroprotection in a rat stroke model and reversed neurological symptoms of estrogen deprivation such as memory problems in female rats lacking ovaries.
Biochem/physiol Actions: DHED is a substrate for nicotinamide adenine dinucleotide phosphate (NADPH)-dependent dehydrogenase/reductase. Its expression in the brain is correlated to neuroprotection functionality.
Biochem/physiol Actions: DHED is an inactive prodrug that selectively produces estrogen solely in the brain.
Symbol GHS08  GHS08
Signal word Danger
Hazard statements H360Df
Precautionary statements P201 - P280 - P308 + P313
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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