RGFP966
SIGMA/SML1652 - ≥98% (HPLC)
Synonym: (2E)
CAS Number: 1396841-57-8
Empirical Formula (Hill Notation): C21H19FN4O
Molecular Weight: 362.40
MDL Number: MFCD26960954
Linear Formula: C21H19FN4O
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C21H19FN4O/c22-18-9-10 |
InChI key | BLVQHYHDYFTPDV-VCABWLAWSA |
Quality Level | 100 ![]() |
SMILES string | NC1=CC(F)=CC=C1NC(/C=C/C( |
solubility | DMSO: 20 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | RGFP966 changes signal-specific primary auditory cortical plasticity. It is highly effective in cardiomyopathy-associated pathologies. |
Biochem/physiol Actions: | RGFP966 is a selective inhibitor of histone deacetylase 3 (HDAC3) with an IC50 value of 80 nM and no inhibition of any other HDACs at concentrations up to 15 μM. In mouse studies, RGFP966 facilitated extinction of cocaine-seeking behavior and enhanced long-term object memory acquisition and consolidation. In a rat study, RGFP966 ameliorated amyloid-β oligomer-induced synaptic plasticity impairment. RGFP966 was also found to reduce proliferation and inducd differentiation in mouse lymphoid and myeloid malignancies. |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |