R-Ketorolac
SIGMA/SML1654 - ≥95% (HPLC)
Synonym: (+)-Ketorolac; (1R)
CAS Number: 66635-93-6
Empirical Formula (Hill Notation): C15H13NO3
Molecular Weight: 255.27
MDL Number: MFCD00871492
Linear Formula: C15H13NO3
Product Type: Chemical
| assay | ≥95% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C15H13NO3/c17-14(10-4- |
| InChI key | OZWKMVRBQXNZKK-LLVKDONJSA |
| optical activity | [α]/D +162 to +178°, c = 1 in methanol |
| Quality Level | 100  |
| SMILES string | O=C(O)[C@H]1C2=CC=C(C(C3= |
| solubility | DMSO: 25 mg/mL, clear |
| storage temp. | −20°C |
| Biochem/physiol Actions: | Ketorolac ((rac)-5-benzoyl-1,2-3H-pyrrolo[1,2a] pyrrole1-carboxylic acid) is a non-steroidal anti-inflammatory drug (NSAID). It is used as a racemic mixture that contains a 1:1 ratio of the R(+) and S(−) stereoisomers. It is broadly used off-label as a parenteral analgesic in children. Ketorolac serves as a non-narcotic analgesic. It prevents the synthesis of prostaglandins, peripheral to the central nervous system. |
| Biochem/physiol Actions: | R-Ketorolac is potent and selective Rho-family GTPases Cdc42 (cell division control protein 42) and Rac1 (Ras-related C3 botulinum toxin substrate 1) allosteric inhibitor that modulates downstream GTPase-dependent physiologic responses critical to tumor metastasis. R-ketorolac significantly inhibits ovarian cancer cell adhesion, migration, and invasion. |
| Biochem/physiol Actions: | R-Ketorolac is potent and selective Rho-family GTPases Cdc42 and Rac1 allosteric inhibitor. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 |
| Precautionary statements | P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |