CBR-5884
SIGMA/SML1656 - ≥98% (HPLC)
Synonym: 5-
CAS Number: 681159-27-3
Empirical Formula (Hill Notation): C14H12N2O4S2
Molecular Weight: 336.39
Linear Formula: C14H12N2O4S2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | paste |
InChI | 1S/C14H12N2O4S2/c1-3-19-1 |
InChI key | QBVIRPJBDIZKBC-UHFFFAOYSA |
Quality Level | 100 |
SMILES string | CC1=C(C(OCC)=O)SC(NC(C2=C |
solubility | DMSO: 20 mg/mL, clear |
storage temp. | 2-8°C |
Application: | CBR-5884 has been used as a 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor to explore the role of PHGDH in Müller cells from different retinal regions and also used in trypan blue exclusion assay to determine the number of viable MYCN cells. |
Biochem/physiol Actions: | CBR-5884 is a cell penetrant, potent and selective noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH) that inhibits proliferation of melanoma and breast cancer lines. CBR-5884 inhibits de novo serine synthesis in in cancer cells. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H315 - H319 - H335 |
Precautionary statements | P305 + P351 + P338 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |