NCT-503
SIGMA/SML1659 - ≥98% (HPLC)
Synonym: N-
CAS Number: 1916571-90-8
Empirical Formula (Hill Notation): C20H23F3N4S
Molecular Weight: 408.48
Linear Formula: C20H23F3N4S
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C20H23F3N4S/c1-14-11-1 |
InChI key | PJNSZIQUFLWRLH-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | CC1=CC(NC(N2CCN(CC3=CC=C( |
solubility | DMSO: 10 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | NCT-503 is an inhibitor of phosphoglycerate dehydrogenase (PHGDH), which catalyzes the first, rate-limiting step of glucose-derived serine synthesis. NCT-503 reduced glucose-derived serine production and suppressed the growth of both PHGDH-dependent cancer cells in culture and in xenograft tumors, and caused G1/S cell cycle arrest in MDA-MB-468 cells. NCT-503 reduced the incorporation of one-carbon units from glucose-derived and exogenous serine into nucleotides, which may contribute to its anticancer activity. NCT-503 had an IC50 value of 2.5 μM for PHGDH and was inactive against a panel of other dehydrogenases and minimal cross-reactivity in a panel of 168 G-protein-coupled receptors (GPCRs). NCT-503 was found to be noncompetitive with respect to both 3-PG and NAD+, and exhibit good stability (>98% after 48 hrs in assay buffer) and aqueous solubility. |
Packaging: | 5, 25 mg in glass bottle |
Recommended products: | NCT-503 Inactive Control, a structurally similar analog of NCT-503, is available from Sigma. To learn more about and purchase NCT-503 inactive control, click here ![]() |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H315 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |