Bafilomycin A1 Ready Made Solution

SIGMA/SML1661 - 0.16 mM in DMSO, from Streptomyces griseus

Synonym: BafA1

CAS Number: 88899-55-2
Empirical Formula (Hill Notation): C₃₅H₅₈O₉
Molecular Weight: 622.83
Linear Formula: C₃₅H₅₈O₉
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1661-.1ML	0.1 mL	$242.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

biological source	Streptomyces griseus
concentration	0.16 mM in DMSO
form	DMSO solution
InChI	1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1
InChI key	XDHNQDDQEHDUTM-JQWOJBOSSA-N
Quality Level	200
shipped in	dry ice
SMILES string	O1[C@@H]([C@H]([C@@H](C[C@]1(O)[C@H]([C@H](O)[C@@H]([C@H]2OC(=O)C(=CC(=C[C@H]([C@H]([C@H](CC(=CC=C[C@@H]2OC)C)C)O)C)C)OC)C)C)O)C)C(C)C
storage temp.	−20°C

Application:	Bafilomycin A1 has been used:• as an endosome acidification inhibitor to study the importance of endosome acidification in the extracellular vesicle uptake and cytosolic release of stably expressing NanoLuc luciferase-tagged Hsp70 (NLuc-Hsp70) in HeLa cells • as a vacuolar-type H⁺-ATPase (V-ATPase) inhibitor to study its effects on autophagic turnover of light chain 3 β (LC3-II) in mice • as an autophagy inhibitor to study its effects on primary rat liver sinusoidal endothelial cells (LSECs) defenestration
Biochem/physiol Actions:	Bafilomycin A1 inhibits autophagy. It may exhibit anti-tumorigenic, anti-parasitic, and anti-neurodegenerative effects. Bafilomycin A1, found in lysosomes and endosomes prevents the acidification of these cell organelles. It also participates in blocking autophagosome-lysosome fusion and autolysosome acidification, steps necessary for maintaining the autophagic flux and cellular homeostasis.
Biochem/physiol Actions:	Bafilomycin A1 is a macrolide antibiotic.
Biochem/physiol Actions:	Bafilomycin A1 is a macrolide antibiotic. Bafilomycin A1 acts as a potent and selective inhibitor of vacuolar-type H⁺-ATPase.
General description:	Bafilomycin A1, a macrolide antibiotic, belongs to the pleomacrolides family. It acts as a potent and selective inhibitor of vacuolar-type H⁺-ATPase. BafA1 can inhibit the viability of MG63 osteosarcoma cells. It can also stimulate mitochondrial dysfunction. BafA1 inhibits the proliferation of different types of cancer cells.
Other Notes:	Bafilomycin A1 solution is provided in concentration of 0.16 mM. Typical concentrations for use in cell culture are 50-100 nM.

WGK Germany	WGK 1
Flash Point(F)	188.6 °F - closed cup
Flash Point(C)	87 °C - closed cup

Storage Temp.	−20°C
UNSPSC	12352200

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