Synonym: (3α,7α)-3,7,15-trihydroxy-12,13-epoxytrichothec-9-en-8-one; 4-Deoxynivalenol; DON; Dehydronivalenol; RD-toxon; Vomitoxin
CAS Number: 51481-10-8
Empirical Formula (Hill Notation): C15H20O6
Molecular Weight: 296.32
Linear Formula: C15H20O6
Product Type: Chemical
| biological source |
Fusarium sp. (Fusarium asiaticum) |
| concentration |
1 mg/mL |
| form |
solution (ethanol: 2-propanol 95:5) |
| InChI |
1S/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/m1/s1 |
| InChI key |
LINOMUASTDIRTM-QGRHZQQGSA-N |
| Quality Level |
200  |
| shipped in |
dry ice |
| storage condition |
protect from light |
| storage temp. |
−20°C |
| Biochem/physiol Actions: |
Deoxynivalenol (DON) is a trichothecene mycotoxin that inhibits the synthesis of DNA and RNA as well as protein synthesis at the ribosomal level. DON induces IL-6 mediated serum hyperelevation of IgA, as well as phosphorylation of extracellular signal regulated protein kinases 1 and 2 (ERK 1,2) and c-Jun N-terminal kinases 1 and 2 (JNK 1,2) in mice. An in vitro study with porcine ovarian granulosa cells suggests a dose dependent association of DON on porcine ovarian functions. It was also shown that LPS and its downstream mediators can interact with DON to modulate proliferative, cytotoxic and apoptotic outcomes in leukocytes in a tissue specific manner. |
| Preparation Note: |
Deoxynivalenol ready-made solution (1 mg/ml in Ethanol: 2-propanol 95:5) can be diluted in aqueous buffers to a working concentration of 0.1-1 μg/ml (1:1000). |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
GHS02,GHS07