Deoxynivalenol Ready Made Solution

SIGMA/SML1664 - 1 mg/mL

Synonym: (3α,7α)-3,7,15-trihydroxy-12,13-epoxytrichothec-9-en-8-one; 4-Deoxynivalenol; DON; Dehydronivalenol; RD-toxon; Vomitoxin

CAS Number: 51481-10-8
Empirical Formula (Hill Notation): C₁₅H₂₀O₆
Molecular Weight: 296.32
Linear Formula: C₁₅H₂₀O₆
Product Type: Chemical

biological source	Fusarium sp. (Fusarium asiaticum)
concentration	1 mg/mL
form	solution (ethanol: 2-propanol 95:5)
InChI	1S/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/m1/s1
InChI key	LINOMUASTDIRTM-QGRHZQQGSA-N
Quality Level	200
shipped in	dry ice
SMILES string	O1[C@]2([C@@H]3O[C@H]4[C@@]([C@]2(C[C@H]3O)C)([C@@H](C(=O)C(=C4)C)O)CO)C1
storage condition	protect from light
storage temp.	−20°C

Biochem/physiol Actions:	Deoxynivalenol (DON) is a trichothecene mycotoxin that inhibits the synthesis of DNA and RNA as well as protein synthesis at the ribosomal level.
Biochem/physiol Actions:	Deoxynivalenol (DON) is a trichothecene mycotoxin that inhibits the synthesis of DNA and RNA as well as protein synthesis at the ribosomal level. DON induces IL-6 mediated serum hyperelevation of IgA, as well as phosphorylation of extracellular signal regulated protein kinases 1 and 2 (ERK 1,2) and c-Jun N-terminal kinases 1 and 2 (JNK 1,2) in mice. An in vitro study with porcine ovarian granulosa cells suggests a dose dependent association of DON on porcine ovarian functions. It was also shown that LPS and its downstream mediators can interact with DON to modulate proliferative, cytotoxic and apoptotic outcomes in leukocytes in a tissue specific manner.
Preparation Note:	Deoxynivalenol ready-made solution (1 mg/ml in Ethanol: 2-propanol 95:5) can be diluted in aqueous buffers to a working concentration of 0.1-1 μg/ml (1:1000).

Storage Temp.	−20°C
UNSPSC	12352200