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4-Hydroxytamoxifen Ready Made Solution

SIGMA/SML1666 - 5 mg/mL in ethanol: isopropanol (95:5)

Synonym: 4-OHT; cis/trans-4-Hydroxytamoxifen

CAS Number: 68392-35-8
Empirical Formula (Hill Notation): C26H29NO2
Molecular Weight: 387.51
Linear Formula: C26H29NO2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1666-1ML 1 mL
 $193.00
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biological source synthetic
concentration 5 mg/mL in ethanol: isopropanol (95:5)
form solution
InChI 1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-
InChI key TXUZVZSFRXZGTL-QPLCGJKRSA-N
Quality Level 200 
shipped in dry ice
storage temp. −20°C
Biochem/physiol Actions: 4-Hydroxytamoxifen is an active metabolite of Tamoxifen. 4-Hydroxytamoxifen is formed by cytochrome P450 2D6 in human liver and is a potent and selective estrogen receptor antagonist. 4-Hydroxytamoxifen has been used to stimulate LC3 lipidation and to form autophagic vesicles in a superoxide-dependent manner. Tamoxifen and 4-Hydroxytamoxifen markedly induce cytochrome P450 3A4 (a major drug-metabolizing enzyme) in primary cultures of human hepatocytes. 4-Hydroxytamoxifen undergoes a cis-trans (E-Z) isomerization, a process that occurs in all common laboratory solvents.
Biochem/physiol Actions: Trans isoform of 4-hydroxytamoxifen possesses antiestrogenic activity, while the cis 4-hydroxytamoxifen serves as a key agonist for estrogen receptor. 4-Hydroxytamoxifen promotes apoptosis via activation of p38 pathway in breast cancer cell cultures.
Preparation Note: 4-Hydroxytamoxifen is provided in a 13 mM solution. The recommended working concentration is 10-100 μM. Therefore, 4-Hydroxytamoxifen Ready Made Solution should be diluted 1:130 - 1:1,300 in cell culture media.
Storage Temp. −20°C
UNSPSC 12352200

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