Tipifarnib

SIGMA/SML1668 - ≥98% (HPLC)

Synonym: (R)-(+)-R 115777; 6-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone; R115777

CAS Number: 192185-72-1
Empirical Formula (Hill Notation): C₂₇H₂₂Cl₂N₄O
Molecular Weight: 489.40
MDL Number: MFCD07772347
Linear Formula: C₂₇H₂₂Cl₂N₄O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1668-5MG	5 mg	$148.00 1/EA	Add To Favorites
45-SML1668-25MG	25 mg	$599.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3/t27-/m1/s1
InChI key	PLHJCIYEEKOWNM-HHHXNRCGSA-N
optical activity	[α]/D 17 to 24°, c = 1 in methanol
Quality Level	100
SMILES string	CN(C1=CC=C([C@](C2=CN=CN2C)(N)C3=CC=C(Cl)C=C3)C=C1C(C4=CC=CC(Cl)=C4)=C5)C5=O
solubility	DMSO: 10 mg/mL, clear
storage temp.	−20°C

Biochem/physiol Actions:	Orally active and potent farnesyltransferase (FTase) inhibitor
Biochem/physiol Actions:	Tipifarnib (R115777) is an orally active and potent farnesyltransferase (FTase) inhibitor that exhibits potent anti-tumorigenic effects. Tipifarnib mechanism of action is not fully understand.
General description:	Pre-clinical studies show that tipifarnib has antiproliferative effects on pancreatic cancer cell lines at clinically relevant concentrations (concentration that inhibits 50% growth [IC50] from 9.5 to 500 nmol/L). It also exhibits marked growth retardation and antiangiogenic effects in a pancreatic cancer xenograft model.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P305 + P351 + P338
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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