Tipifarnib
SIGMA/SML1668 - ≥98% (HPLC)
Synonym: (R)-(+)-R 115777; 6-
CAS Number: 192185-72-1
Empirical Formula (Hill Notation): C27H22Cl2N4O
Molecular Weight: 489.40
MDL Number: MFCD07772347
Linear Formula: C27H22Cl2N4O
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C27H22Cl2N4O/c1-32-16- |
InChI key | PLHJCIYEEKOWNM-HHHXNRCGSA |
optical activity | [α]/D 17 to 24°, c = 1 in methanol |
Quality Level | 100 |
SMILES string | CN(C1=CC=C([C@](C2=CN=CN2 |
solubility | DMSO: 10 mg/mL, clear |
storage temp. | −20°C |
Biochem/physiol Actions: | Tipifarnib (R115777) is an orally active and potent farnesyltransferase (FTase) inhibitor that exhibits potent anti-tumorigenic effects. Tipifarnib mechanism of action is not fully understand. |
General description: | Pre-clinical studies show that tipifarnib has antiproliferative effects on pancreatic cancer cell lines at clinically relevant concentrations (concentration that inhibits 50% growth [IC50] from 9.5 to 500 nmol/L). It also exhibits marked growth retardation and antiangiogenic effects in a pancreatic cancer xenograft model. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H315 - H319 - H335 |
Precautionary statements | P305 + P351 + P338 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |