NCT-503 Inactive Control

SIGMA/SML1671 - ≥98% (HPLC)

Synonym: N-(4,6-Dimethylpyridin-2-yl)-4-(pyridin-4-yl)piperazine-1-carbothioamide

CAS Number: 1914971-16-6
Empirical Formula (Hill Notation): C₁₇H₂₁N₅S
Molecular Weight: 327.45
Linear Formula: C₁₇H₂₁N₅S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1671-5MG	5 mg	$119.00 1/EA		Add To Favorites
45-SML1671-25MG	25 mg	$480.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C17H21N5S/c1-13-11-14(2)19-16(12-13)20-17(23)22-9-7-21(8-10-22)15-3-5-18-6-4-15/h3-6,11-12H,7-10H2,1-2H3,(H,19,20,23)
InChI key	ITLPIAAGIQAGRA-UHFFFAOYSA-N
Quality Level	100
SMILES string	CC1=CC(NC(N2CCN(C3=CC=NC=C3)CC2)=S)=NC(C)=C1
solubility	DMSO: 5 mg/mL, clear (warmed)
storage temp.	2-8°C

Application:	NCT-503 Inactive Control has been used as a small molecule inhibitor of phosphoglycerate dehydrogenase in neuroblastoma cells.
Biochem/physiol Actions:	NCT-503 Inactive Control is the inactive control probe for NCT-503, which is an inhibitor of phosphoglycerate dehydrogenase (PHGDH), the enzyme that catalyzes the first, rate-limiting step of glucose-derived serine synthesis. NCT-503 Inactive Control has an IC₅₀ value >57 μM for PHGDH. NCT-503 has an IC₅₀ value of 2.5 μM for PHGDH. NCT-503 Inactive Control is water soluble and has good stability, similar to NCT-503.
Biochem/physiol Actions:	NCT-503 Inactive Control is the inactive control probe for NCT-503, which is an inhibitor of phosphoglycerate dehydrogenase (PHGDH).
Other Notes:	The active PHGDH inhibitor, NCT-503, is available from Sigma. To learn more about and purchase NCT-503, click here .
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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