JT010

SIGMA/SML1672 - ≥98% (HPLC)

Synonym: 2-Chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-methoxypropyl)-acetamide

CAS Number: 917562-33-5
Empirical Formula (Hill Notation): C₁₆H₁₉ClN₂O₃S
Molecular Weight: 354.85
Linear Formula: C₁₆H₁₉ClN₂O₃S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1672-5MG	5 mg	$119.00 1/EA		Add To Favorites
45-SML1672-25MG	25 mg	$480.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C16H19ClN2O3S/c1-21-9-3-8-19(15(20)10-17)16-18-14(11-23-16)12-4-6-13(22-2)7-5-12/h4-7,11H,3,8-10H2,1-2H3
InChI key	KZMAWJRXKGLWGS-UHFFFAOYSA-N
Quality Level	100
SMILES string	O=C(N(C1=NC(C2=CC=C(OC)C=C2)=CS1)CCCOC)CCl
solubility	DMSO: 10 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	JT010 is a non-cytotoxic and highly stable (>90% remains after 2 h in 1 mM DTT or 2-mercaptoethanol) chloroacetamido warhead-carrying thiazole derivative that acts as a potent and TRPA1-selective channel activator via covalent modification of TRPA1 active site Cys621. JT0101 stimulates calcium influx in TRPA1-transfected HEK293 cells in a dose-dependent manner (EC₅₀ = 650 pM) with excellent selectivity over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC₅₀ >1 μM).
Biochem/physiol Actions:	JT010 is a non-cytotoxic and highly stable chloroacetamido warhead-carrying thiazole derivative.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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