Ex26
SIGMA/SML1680 - ≥98% (HPLC)
Synonym: 1-[[[5′-[[1-(4-Chloro-3-methylphenyl)ethyl]amino]-2′-fluoro-3,5-dimethyl[1,1′-biphenyl]-4-yl]carbonyl]amino]-cyclopropanecarboxylic acid
CAS Number: 1233332-37-0
Empirical Formula (Hill Notation): C28H28ClFN2O3
Molecular Weight: 494.98
Linear Formula: C28H28ClFN2O3
Product Type: Chemical
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1680-25MG.
This image depicts SML1680-25MG.
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI key | YVHNBORUVLWCKF-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | ClC1=CC=C(C(C)NC2=CC=C(F) |
| solubility | DMSO: 25 mg/mL, clear |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | Ex26 is a peripherally-restricted biphenylcarboxamide derivative that acts as a highly potent and subtype-selective S1P1 antagonist (IC50 = 0.93 nM against S1PR1 and >3.1 μM against S1PR2/3/4/5). Ex26 significantly elevates CpG-A-stimulated interferon (IFN) production in plasmacytoid dendritic cell culture (10 μM) and prevents S1P1 agonist-induced S1P1 receptor internalization and polyubiquitinylation in HEK cells (0.1-1,000 nM). Ex26 induces lymphocyte sequestration (ED50 = 0.06 mg/kg, i.p.) in lymph nodes and pulmonary edema (2 hr post 30 mg/kg i.p.) in mice, leading to the inhibition of lymphocyte and thymocyte egress (0.1 mg/kg/hr continuously for 3 days after a loading dose of 3 mg/kg). Ex26 has been shown to ameliorate experimental autoimmune encephalomyelitis (EAE) in a mouse MS model and elevate CpG-A-stimulated serum IFN upregulation in mice in vivo (30 mg/kg/d, i.p.). |
| Biochem/physiol Actions: | Ex26 is a peripherally-restricted biphenylcarboxamide derivative that acts as a highly potent and subtype-selective S1P1 antagonist. |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard statements | H413 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |