Endosidin2

SIGMA/SML1681 - ≥98% (HPLC)

Synonym: (E)-3-Fluoro-N′-(4-hydroxy-3-iodo-5-methoxybenzylidene)benzohydrazide

CAS Number: 1839524-44-5
Empirical Formula (Hill Notation): C₁₅H₁₂FIN₂O₃
Molecular Weight: 414.17
Linear Formula: C₁₅H₁₂FIN₂O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1681-5MG	5 mg	$108.00 1/EA	Add To Favorites
45-SML1681-25MG	25 mg	$435.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C15H12FIN2O3/c1-22-13-6-9(5-12(17)14(13)20)8-18-19-15(21)10-3-2-4-11(16)7-10/h2-8,20H,1H3,(H,19,21)/b18-8+
InChI key	UIADDCURKKFTFW-QGMBQPNBSA-N
Quality Level	100
SMILES string	FC1=CC(C(N/N=C/C2=CC(OC)=C(O)C(I)=C2)=O)=CC=C1
solubility	DMSO: 20 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:

Endosidin2 is a cell-permeable benzylidene-benzohydrazide based compound that binds to the exocyst component of 70 kDa (EXO70) subunit of exocyst complex (Kd = 253 μM for interaction with EXO70A1) and reduces exocytosis and endosomal recycling in plant and mammalian cells. Displays good aqueous stability. Endosidin2 has shown to disrupt the trafficking of proteins between the plasma membrane and endosome, which leads to enhanced trafficking to the vacuole for degradation. It is reported to inhibit the recycling of endocytosed transferrin to plasma membrane in HeLa cells, and can target multiple isoforms of EXO70 in mammals, resulting in misregulation of exocytosis.

Packaging:

5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319
Precautionary statements	P305 + P351 + P338
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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