CDN1163

SIGMA/SML1682 - ≥98% (HPLC)

Synonym: 4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)-benzamide

CAS Number: 892711-75-0
Empirical Formula (Hill Notation): C₂₀H₂₀N₂O₂
Molecular Weight: 320.39
MDL Number: MFCD07177494
Linear Formula: C₂₀H₂₀N₂O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1682-5MG	5 mg	$108.00 1/EA		Add To Favorites
45-SML1682-25MG	25 mg	$435.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C20H20N2O2/c1-13(2)24-17-11-9-16(10-12-17)20(23)22-18-6-4-5-15-8-7-14(3)21-19(15)18/h4-13H,1-3H3,(H,22,23)
InChI key	GVGVYDCVFBGALZ-UHFFFAOYSA-N
Quality Level	100
SMILES string	CC1=NC2=C(NC(C3=CC=C(OC(C)C)C=C3)=O)C=CC=C2C=C1
solubility	DMSO: 5 mg/mL, clear (warmed)
storage temp.	2-8°C

Biochem/physiol Actions:	CDN1163 is an allosteric activator of sarco/ endoplasmic reticulum Ca2+-ATPase (SERCA) that potently lowered fasting blood glucose, improved glucose tolerance and ameliorated hepatosteatosis in ob/ob mice. Additionally CDN1163 induces significant reduction in adipose tissue weight with no change in lean mass in ob/ob mice. CDN1163 has no effect on glucose levels or body weight in lean control mice.
Biochem/physiol Actions:	CDN1163 treatment declined the hepatic expression of genes implicated in gluconeogenesis and lipogenesis as well as attenuated endoplasmic reticulum (ER) stress response and ER stress-induced apoptosis. CDN1163 interacts with sarco/endoplasmic reticulum Ca²⁺-ATPase (SERCA) and enhances ER Ca²⁺ content.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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