Synonym: 2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one; 5,7-Dihydroxy-3′,4′,6-trimethoxyflavone; NSC 122413
CAS Number: 22368-21-4
Empirical Formula (Hill Notation): C18H16O7
Molecular Weight: 344.32
MDL Number: MFCD13194819
Linear Formula: C18H16O7
Product Type: Chemical
| assay |
≥98% (HPLC) |
| biological source |
(Isolated from Artemisia sp.) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C18H16O7/c1-22-12-5-4-9(6-14(12)23-2)13-7-10(19)16-15(25-13)8-11(20)18(24-3)17(16)21/h4-8,20-21H,1-3H3 |
| InChI key |
DRRWBCNQOKKKOL-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=CC(O)=C(OC)C(O)=C31 |
| solubility |
DMSO: 20 mg/mL, clear |
| storage condition |
desiccated |
| |
protect from light |
| storage temp. |
−20°C |
| Application: |
Eupatilin has been used to investigate its inhibitory effects on intracranial hemorrhage (ICH)-induced inflammation and its anti-inflammatory mechanisms in mouse BV2 cells, in vitro. It has also been used as a standard for its quantitative estimation in Artemisia extracts by microcolumn high performance liquid chromatography with diode array (HPLC-DAD) assay. |
| Biochem/physiol Actions: |
Eupatilin is a flavone with anti-oxidative, anti-inflammatory, and anti-cancer properties. |
| Biochem/physiol Actions: |
Eupatilin is an important constituent in the leaves of Artemisia argyi and also an active component of DA-9601. It exhibits anti-apoptotic effects. Eupatilin provides protection against tumor necrosis factor α (TNF-α)-mediated inflammation in human umbilical vein endothelial cells. It is used in the treatment of gastritis and peptic ulcers. Eupatilin safeguards gastric epithelial cells from oxidative damage and smooth muscle cells from indomethacin-induced cell damage. Eupatilin lowers bile acid-stimulated hepatocyte apoptosis. |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
