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ZM323881 hydrochloride

SIGMA/SML1691 - ≥98% (HPLC)

Synonym: 5-((7-Benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methylphenol hydrochloride; ZM-323881 hydrochloride

CAS Number: 193000-39-4
Empirical Formula (Hill Notation): C22H18FN3O2 · HCl
Molecular Weight: 411.86
Linear Formula: C22H18FN3O2 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1691-5MG 5 mg
 $125.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C22H18FN3O2.ClH/c1-14-9-18(23)20(11-21(14)27)26-22-17-8-7-16(10-19(17)24-13-25-22)28-12-15-5-3-2-4-6-15;/h2-11,13,27H,12H2,1H3,(H,24,25,26);1H
InChI key AVRHWGLIYGJSOD-UHFFFAOYSA-N
Quality Level 100 
SMILES string Fc1c(cc(c(c1)C)O)Nc2ncnc3c2ccc(c3)OCc4ccccc4.Cl
solubility DMSO: 10 mg/mL, clear
storage condition desiccated
storage temp. 2-8°C
Biochem/physiol Actions: ZM323881 is a selective inhibitor of VEGFR-2 with an IC50 value of 2 nM. ZM323881 is selective for VEGFR-2 over VEGFR-1 and other receptor tyrosine kinases including PDGFRβ, FGFR1, EGFR and erbB2. ZM323881 inhibited VEGF-A-induced endothelial cell proliferation with an IC50 value of 8 nM.
Biochem/physiol Actions: ZM323881 is a selective inhibitor of VEGFR-2.
Biochem/physiol Actions: ZM323881 is also known as (5‐{[7‐(benzyloxy) quinazolin‐4‐yl]amino}‐4‐fluoro‐2‐methylphenol). It is capable of blocking the efflux function and altering breast cancer resistant protein (BCRP)-related multidrug resistance (MDR).
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P301 + P312 + P330
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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