AS8351
SIGMA/SML1692 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 796-42-9
Empirical Formula (Hill Notation): C17H13N3O2
Molecular Weight: 291.30
MDL Number: MFCD00033110
Linear Formula: C17H13N3O2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C17H13N3O2/c21-16-6-5- |
InChI key | WQSHHAVECQJKLX-YBFXNURJSA |
Quality Level | 100 |
SMILES string | OC1=CC=C(C=CC=C2)C2=C1/C= |
solubility | DMSO: 20 mg/mL, clear |
storage condition | desiccated |
storage temp. | −20°C |
Biochem/physiol Actions: | AS8351 is an iron chelator that has been found to inhibit of histone demethylase KDM5B (JARID1B), a histone H3K4 demethylase involved in regulation of cell proliferation and stem cell self-renewal and differentiation. AS8351 is thought to inhibit KDM5B by competing with a-ketoglutarate for chelating iron that KDM5B requires as a co-factor. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H315 - H319 - H335 |
Precautionary statements | P305 + P351 + P338 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |