AS8351

SIGMA/SML1692 - ≥98% (HPLC)

Synonym: 2-Hydroxy-1-naphthylaldehyde isonicotinoylhydrazone; 311 Iron Chelator; AS-8351; NSC-51355

CAS Number: 796-42-9
Empirical Formula (Hill Notation): C₁₇H₁₃N₃O₂
Molecular Weight: 291.30
MDL Number: MFCD00033110
Linear Formula: C₁₇H₁₃N₃O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1692-5MG	5 mg	$101.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C17H13N3O2/c21-16-6-5-12-3-1-2-4-14(12)15(16)11-19-20-17(22)13-7-9-18-10-8-13/h1-11,21H,(H,20,22)/b19-11+
InChI key	WQSHHAVECQJKLX-YBFXNURJSA-N
Quality Level	100
SMILES string	OC1=CC=C(C=CC=C2)C2=C1/C=N/NC(C3=CC=NC=C3)=O
solubility	DMSO: 20 mg/mL, clear
storage condition	desiccated
storage temp.	−20°C

Biochem/physiol Actions:	AS8351 is an iron chelator that has been found to inhibit of histone demethylase KDM5B (JARID1B), a histone H3K4 demethylase involved in regulation of cell proliferation and stem cell self-renewal and differentiation. AS8351 is thought to inhibit KDM5B by competing with a-ketoglutarate for chelating iron that KDM5B requires as a co-factor.
Biochem/physiol Actions:	AS8351 is an iron chelator that has been found to inhibit of histone demethylase KDM5B (JARID1B).
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P305 + P351 + P338
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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